SHR-A1904 Combinations in CLDN18.2-Positive Advanced Solid Tumor

Inclusion Criteria: 1. Age 18 to 75 years old (including boundary values); 2. Volunteer to participate in this clinical study and sign informed consent; 3. ECOG score 0-1; 4. Expected survival ≥3 months; 5. Pathologically confirmed locally advanced unresectable or metastatic solid tumors; 6. positive CLDN18.2 expression in tumor tissue; 7. There is at least one measurable lesion that meets the RECIST 1.1 criteria; 8. Adequate bone marrow and organ function. Exclusion Criteria: 1. Plan to receive any other antitumor therapy during this trial; Received other investigational drugs or treatments that are not on the market within 4 weeks prior to the first administration; Anti-tumor therapy, such as chemotherapy, radiotherapy, biotherapy, targeted therapy or immunotherapy, was received within 4 weeks before the first administration of the study drug. Palliative radiotherapy or local therapy within 2 weeks before the first administration of the study drug; Had major surgery other than diagnosis or biopsy within the 4 weeks prior to the first administration or randomization and required elective surgery during the trial. 2. HER2 expression in tumor tissue is positive. 3. The adverse reactions of previous anti-tumor therapy has not recovered to NCI-CTCAE v5.0 grade≤ 1. 4. Has ≥ grade 2 peripheral sensory neuropathy. 5. Has an allergic reaction to any of the components treated in this study, or are allergic to humanized monoclonal antibody products. 6. Has a history or current history of meningeal metastasis; or active brain metastases. 7. Presence of dysphagia or other factors affecting the use of oral medications. 8. Additional malignancy within the five years prior to the first administration or randomization. 9. Has an active autoimmune disease or a history of autoimmune disease. 10. Received systemic use of corticosteroids or other immunosuppressants for immunosuppressive effects within 14 days prior to the first administration or randomization. 11. Has a history of clinically significant lung disease. 12. Has serosal effusion ≥ grade 3 (based on NCI CTCAE5.0 criteria). 13. There was an active infection requiring systemic treatment within 2 weeks prior to the first administration or randomization. 14. A history of immunodeficiency, including a positive HIV test; Presence of active hepatitis B or hepatitis C. 15. People who have previously received allogeneic hematopoietic stem cell transplantation or organ transplantation. 16. Has severe cardiovascular and cerebrovascular diseases. 17. Gastrointestinal perforation and/or gastrointestinal fistula within the last 6 months prior to the first administration or randomization; Active gastrointestinal bleeding occurred 3 months before the first administration or randomization. 18. In the investigator's judgment, the subject has other factors that could have affected the study results or led to the forced termination of the study.