Neuroimage Genome Study of Neuroplasticity Associated With Microgravity

Chinese PLA General Hospital26 enrolled

Overview

This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and white matter changes under microgravity exposure, screen and identify representative image markers, so as to provide decision-making information for the cognitive status changes of relevant personnel under microgravity environment.

MRI has the advantage of non-invasive and non-radiation, and imaging the human brain after exposure to microgravity can reveal the neuroplastic changes in the astronaut's brain and discover the characteristics of functional activities behind it. The purpose of this study is to explore the image features and cognitive state related information related to the changes of human brain neuroplasticity under microgravity environment, and to identify the related image markers. At the same time, the pathophysiological mechanism is preliminarily discussed in this study. This study is helpful for us to explore the sensitivity of different brain structures and brain functions to space microgravity environment, so as to further understand the role and influence of space missions on brain health.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Microgravity Neuroplasticity MRI Repeatable Battery for the Assessment of Neuropsychological Status

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male aged 18-60 years * No mental or other neurological disorders, no history of drug or alcohol abuse * Generally in good condition, no clear major physical diseases, no hearing disorders * No metal foreign bodies in the body, no contraindications to MRI scanning * No claustrophobia * Agree to participate in the clinical study and sign the informed consent Exclusion Criteria: * There are electronic implants or metal foreign bodies, such as cardiac pacemakers * People with aneurysm surgery and intracranial aneurysm clip * People who have had heart surgery and used artificial heart valves * Having family planning * Uncontrolled epilepsy or mental illness, can't cooperate with MRI examination * Severe claustrophobia, can't cooperate with magnetic resonance examination * Other circumstances that the clinical trial personnel consider inappropriate to participate in the study

Outcomes

Primary Outcomes

Local brain functional activity

Based on resting-state functional MRI images, the changes of local brain functional activity before and after the Head-Down tilt Bed Rest test were compared.