Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia

University of Padova15 enrolled

Overview

qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia. No trials have compared them, so with this trial authors want to explore the correlations between them.

qNOX and ANI are two indexes evaluting the anaglesia conduction during general anesthesia. Even if the aim is the same (to measure the nociception level) these indexes utilize different algorithm: the qNOX is derived by the electroencephalogrm (EEG), the ANI is derived by heart rate variation. No trials have compared them, so with this trial authors want to explore the correlations between them, and if altered values of one of them is stronger related to postoperative pain and delirium.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Analgesia

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and remifentanil (Eleveld model) Exclusion Criteria: * Neurological disease * Psychiatric disease * Obesity * Regional anesthesia performed

Locations (1)

Treviso Regional Hospital

Treviso, TV, Italy

Outcomes

Primary Outcomes

Correlation between qNOX and ANI values

qNOX and ANI values will be compared to check the correspondance in evaluting analgesia level

Time frame: qNOX, ANI, pupoillometry values, propofol and remifentanil concentration during induction, intubation, after post-tetanic count at the trend-of-four and maintenance phase of general anesthesia detected with target controlled inusion will be paired.

Secondary Outcomes

Correlation between qNOX from CONOX and Analgesia nocicpetion index (ANI) values and postoperative pain

Evaluate if qNOX or ANI values relate to postoperative pain

Time frame: qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative pain, evalued with NRS score after 24 hours

Correlation between qNOX from CONOX and analgesia nocicpetion index (ANI) values and postoperative delirium

Evaluate if qNOX or ANI values relate to postoperative delirium

Time frame: qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative delirium, evaluated with CAM and 4AT score after 24 hours

Data from ClinicalTrials.gov

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