Efficacy and Safety of Bismuth Quadruple Therapy Containing Cefuroxime and Tetracycline as First-line Therapy for Eradicating Helicobacter Pylori in Patients Allergic to Penicillin

Inclusion Criteria: 1. Age 18-70 years old, regardless of gender. 2. History of penicillin allergy. 3. Helicobacter pylori infection. 4. Patients who have not previously received Helicobacter pylori eradication therapy. Exclusion Criteria: 1. Medication history of bismuth and antibiotics within 4 weeks; PPIs and P-CABs within 2 weeks. 2. Serious underlying diseases, such as liver insufficiency, renal insufficiency, malignant tumors, etc. 3. Previous gastric or esophageal surgery. 4. History of allergy to test drugs. 5. Pregnant and lactating women and those unwilling to use contraception during the trial period. 6. Have other behaviors that may increase the risk such as alcohol and drug abuse. 7. Those unable to provide informed consent.