Risk Stratification, Early Prevention and Treatment Strategies for Arrhythmogenic Cardiomyopathy

First Affiliated Hospital Xi'an Jiaotong University1,500 enrolled

Overview

This study will include patients diagnosed with Arrhythmogenic cardiomyopathy (ACM) in the First Affiliated Hospital of Xi 'an Jiaotong University and other centers, and collect clinical data and biological samples of patients with different ACM phenotypes. Through the establishment of disease cohort and long-term follow-up, to explore the disease characteristics, development law, clinical characteristics, natural course of disease and long-term prognosis of ACM.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Arrhythmogenic Cardiomyopathy

Interventions

Diagnosis of ACMOTHER

Definite ACM diagnosis is based on the consensus-based 2010 Task Force Criteria, which include major and minor criteria in six categories (depolarization and repolarization abnormalities, arrhythmia, imaging, histology, and family history/genetics). Among these, repolarization abnormalities (T-wave inversion in the precordial leads) constitute the most commonly observed, followed by frequent premature ventricular complex. With regards to imaging techniques, both the presence of wall motion abnormalities and an abnormal ventricular volume or function are required for fulfilment. Definite ACM consists of two major criteria or one major and two minor criteria or four minor criteria from different categories. Borderline ACM consists of one major and one minor criterion or three minor criteria from different categories.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>18 years old. * The diagnosis of ACM was confirmed by cardiac ultrasound, electrocardiogram, magnetic resonance angiography, pathological examination and gene sequencing. * Patients or their families agreed to participate in the study and authorized informed consent. Exclusion Criteria: * Incomplete clinical data. * Do not agree to the inclusion or refuse to authorize the informed consent.

Outcomes

Primary Outcomes

Change in the incidence of mortality rate

The survival status will be obtained from the medical records and phone calls to patients or their family members.

Time frame: At diagnosis, before discharge (about 7 days), 1, 3, 6, 9 month, 1, 2, 3 year.