This 4-week clinical study was designed to examine the antibacterial efficacy of brushing with a 0.454% stannous fluoride toothpaste with potassium nitrate and pyrophosphate compared to a toothpaste containing 0.76% MFP (marketed as Colgate Cavity Protection Toothpaste) in different regions of the mouth (dental plaque, tongue, cheek, gum surface and in saliva) 12 hours post-brushing (overnight) after 2 and 4 weeks of product use.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
product containing 0.45% stannous fluoride
product containing 0.76% sodium monofluorophosphate
M U International Oral Science Research, Ltd.
Bangkok, Bangkok, Thailand
Whole mouth scores of dental plaque
Measuring the dental plaque using the Turesky Modification of Quigley-Hein.Subjects presenting with whole mouth scores for dental plaque of 1.5 or more \[Turesky Modification of plaque will be enrolled. Quigley-Hein.
Time frame: baseline, 2 week & 4 week
Measurement of total bacterial counts on tongue
Scrapings from the surface of the tongue. All collected samples will be placed in sterile vials, labeled with subject information and transferred to the laboratory for analysis
Time frame: baseline, 2 week & 4 week
Measurement of total bacterial counts on cheek
Scrapings from the surface of the cheek mucosa. All collected samples will be placed in sterile vials, labeled with subject information and transferred to the laboratory for analysis
Time frame: baseline, 2 week & 4 week
Measurement of gingivitis
Using the Loe-Silness index.Subjects presening will 1.0 or more for gingivitis \[Loe-Silness\] will be enrolled.
Time frame: baseline, 2 week & 4 week
Measurement of total bacterial counts in saliva
Collected samples in saliva will be placed in sterile vials, labeled with subject information and transferred to the laboratory for analysis
Time frame: baseline, 2 week & 4 week
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