Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment

Akdeniz University30 enrolled

Overview

The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ß).

Bactericidal/permeability-increasing proteins (BPI) specific and powerful effect against Gram negative bacteria and their LPSs is completely observable in biological fluids such as plasma, serum, and whole blood. Objective: It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta (IL-1 β) levels in gingival fluid before and after non-surgical periodontal treatment (NSPT)in patients with periodontal disease. Method: Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study. Before NSPT, the clinical parameters of plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAS), bleeding on probing (BOP) were measured. The gingival fluid samples were taken using the paper strip method. The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment. ELISA method was used for the analysis of the samples

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontitis

Interventions

Non-surgical periodontal treatmentPROCEDURE

Scaling and root planing in two sessions over the course of a 48-hour period comprised the standard treatment procedure

Eligibility

Sex: ALLMin age: 22 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria Systemically healthy, * Stage II or III, Grade A periodontitis * Having at least 20 permanent teeth (excluding third molars and any tooth loss induced by -non-periodontal causes). Exclusion Criteria: Smoking, * use of alcohol; pregnancy or lactation; intake ofantibiotics, steroidal or non-steroidal anti-inflammatory drugs within the last 6 months * having received periodontal treatment within the last 6 months

Locations (2)

Akdeniz Üniversity

Antalya, Turkey (Türkiye)

Akdeniz Üniversitesi Diş Hekimliği Fakültesi

Antalya, Turkey (Türkiye)

Outcomes

Primary Outcomes

Gingival crevicular fluid Bactericidal/permeability-increasing proteins levels

Gingival Crevicular Fluid Bactericidal Permeability Increasing Protein levels in periodonitis patients after Non-surgical periodontal treatment

Time frame: through study completion, an average of 1 year

Secondary Outcomes

Gingival crevicular fluid interleukin-1Beta levels

Gingival Crevicular Fluid IL-1β in periodonitis patients after Non-surgical periodontal treatment

Time frame: through study completion, an average of 1 year

Data from ClinicalTrials.gov

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