The goal of this observational cohort study is to learn about the etiology, natural course, therapeutic effect and outcome of recurrent acute pancreatitis patients. The main question it aims to answer is: Does endoscopic intervention, surgery or conservative treatment reduce the recurrence of acute pancreatitis? What are the risk factors affecting the recurrence of acute pancreatitis? Patients will be closely followed and clinical information will be recorded.
Acute pancreatitis is one of the most common causes of acute hospital admission, which is unpredictable and contributes to high health-care costs even death. Recurrent acute pancreatitis is defined as two or more discrete episodes of acute pancreatitis, and has an estimated annual incidence of 8-10 per 100 000. Cholelithiasis, alcohol and Hyperglyceremia are the most commonly recognized causes of acute pancreatitis. About 80% of RAP patients can be identified through routine investigations identify (include proper history, physical examination, CT, MRI, endoscopic ultrasound); however, in up to 20% of cases whose cause remains unclear are known as idiopathic RAP. For RAP patients with clear cause, removal of the cause can effectively reduce or prevent recurrence. For patients with idiopathic RAP, the treatment options are not clear and have been subject to debate. At present, the natural course, outcome and therapeutic effect of RAP is still not clear. Therefore, the prospective cohort can clarify the clinical characteristics of RAP more comprehensively and deeply and to accumulate evidence for treatment.
Study Type
OBSERVATIONAL
Enrollment
2,000
Personal information and treatment of the enrolled subjects will be collected.
Changhai Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGRecurrence rate of acute pancreatitis
Acute pancreatitis is diagnosed according to the revised Atlanta classification, which requires 2 of the 3 following criteria: (1) abdominal pain suggestive of pancreatitis, (2) serum amylase and/or lipase greater than 3 times the upper limit of normal, (3) and crosssectional imaging (CT or MRI) findings consistent with acute pancreatitis.
Time frame: Through study completion, an average of 1 year
Proportion of patients with different treatment
Treatment mainly contains conservative treatment, surgery, endoscopic intervention, etc. Collect relevant data through medical record.
Time frame: Through study completion, an average of 1 year
Characteristics of acute pancreatitis
Collect relevant data through medical record. Characteristics of acute pancreatitis includ etiology, frequency, severity and length of hospital.
Time frame: Through study completion, an average of 1 year
Proportion of patients wtih pain in RAP patients
Collect relevant data through pain assessment scales which include severity, frequency, time of duration and other characteristics of pancreatic pain.
Time frame: Through study completion, an average of 3 year
Proportion of patients with chronic pancreatitis
Proportion of patients who developed chronic pancreatitis.
Time frame: Through study completion, an average of 3 year
Evaluation of quality of life
The level of quality of life in RAP patients is measured using the SF-36.
Time frame: Through study completion, an average of 3 year
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Evaluation of psychological condition
The psychological condition of RAP patients is measured using DASS-21.
Time frame: Through study completion, an average of 3 year