Citicoline & Antioxidants in Glaucoma

University of Naples60 enrolled

Overview

To evaluate the long-term effects of oral citicoline, vitamins A, B, C and E, and blackcurrant therapy in patients with primary open-angle glaucoma (POAG) using optical coherence tomography (OCT), OCT angiography (OCTA) and microperimetry parameters.

AIMS: To evaluate the long-term effects of oral citicoline, vitamins A, B, C and E, and blackcurrant therapy in patients with primary open-angle glaucoma (POAG) using optical coherence tomography (OCT), OCT angiography (OCTA) and microperimetry parameters. METHODS: Fifteen patients with POAG (treated group) received one soluble liquid sachet daily for 20 days a month of a complementary dietary supplement containing in fixed combination citicoline, vitamins A, B, C, and E, and blackcurrant for 1 year. Fifteen age-matched subjects affected by POAG were given a placebo and served as a control group. The patients underwent best corrected visual acuity (BCVA), Goldmann applanation tonometry, microperimetry examination, OCT, and OCTA at the beginning of the study and then at 1, 6 and 12 months.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glaucoma, Open-Angle

Interventions

Citicoline blackcurrant supplementDIETARY_SUPPLEMENT

Citicoline, Vitamins A, B, C and E, and Blackcurrant

Eligibility

Sex: ALLMin age: 30 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of POAG * aged between 18 and 75 years * Patients with controlled intraocular pressure (IOP) below 20 mmHg, who had been on the same topical hypotensive therapy for at least 3 months * myopia less than 5 diopters (D) were considered eligible for inclusion. Exclusion Criteria: * IOP levels exceeding 21 mmHg, * hyper-sensitivity to citicoline, * a history of optic neuritis, * previous glaucoma or retinal surgery, * prior cataract or refractive surgery, * macular degeneration or other retinal disorders, * any systemic diseases that could potentially lead to neurodegeneration (e.g., multiple sclerosis, diabetes)

Locations (1)

University of Naples Federico II

Naples, Italy

Outcomes

Primary Outcomes

Evaluation of Ganglionar cells complex (GCC)

evaluate the long-term effects of oral citicoline, vitamins A, B, C and E, and blackcurrant therapy in patients with primary open-angle glaucoma (POAG) on GCC using optical coherence tomography (OCT)

Time frame: From enrollment to the end of treatment at 1 year

Secondary Outcomes

Evaluation of Retinal nerve fiber layer (RNFL)

evaluate the long-term effects of oral citicoline, vitamins A, B, C and E, and blackcurrant therapy in patients with primary open-angle glaucoma (POAG) on RNFL using optical coherence tomography (OCT)

Time frame: From enrollment to the end of treatment at 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.