A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors

Inclusion Criteria: 1. Patients with histologically verified diagnosis of dermoid tumor 2. The presence of progressive, symptomatic or functionally significant DF. 3. Written Informed consent to participate in the study 4. Age from 18 to 75 years 5. The functional status of the patient according to the ECOG 0-2 scale 6. Normal renal function (estimated creatinine clearance 60 ml/min); 7. Normal level of bilirubin and liver enzymes (AST, ALT - no more than 3 norms); 8. Left ventricular ejection fraction \> 55% 9. Satisfactory bone marrow function (hemoglobin level 9 g/dl, neutrophil count 1.5 thousand/ml, platelet count \< 100 thousand/ml); Exclusion Criteria: 1. The inability to obtain informed consent to participate in the study 2. Synchronous or metachronous cancer 3. Clinically significant diseases of the cardiovascular system 4. Clinically significant CNS diseases 5. Previous grade 2 polyneuropathy and above 6. Current infection or other severe or systemic disease that increases the risk of complications of therapy 7. Pregnancy, lactation