Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
176
Dexmedetomidine (Precedex) loadings of 1 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
Dexmedetomidine (Precedex) loadings of 0.5 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
Dexmedetomidine (Precedex) loadings of 0.25 μg/kg, then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
Cairo university
Cairo, Egypt
Oxygenation by the end study
PaO2/Fraction of inspired oxygen
Time frame: UP TO 6 HOURE
Intraoperative dynamic lung compliance
tidal volume/ (peak airway pressure -PEEP)
Time frame: up to 6 hours
Intraoperative static lung compliance
Tidal volume/ (plateau pressure - PEEP)
Time frame: UP TO 6 HOURE
Physiological dead space
1.14 (PaCO2-EtCO2)/ PaCO2-0.005
Time frame: UP TO 6HOURE
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