This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief. The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.
Study Type
OBSERVATIONAL
Enrollment
30
Heat stimulation at a painful, but to the subject tolerable level.
Danish Pain Research Center
Aarhus N, Denmark
RECRUITINGC-fiber excitability
Changes in C-fiber excitability measured in latency changes after electrical stimulation with a paired pulse protocol compared to an unpaired electrical stimulus.
Time frame: Through study completion, an average of 6 months
Action potential duration (ms)
Averaged analysis from repeated measures of a single nerve fiber signal.
Time frame: Through study completion, an average of 6 months
Action potential amplitude (V)
Averaged analysis from repeated measures of a single nerve fiber signal.
Time frame: Through study completion, an average of 6 months
Heart-rate variability (ms)
Comparison of heart-rate variability during experimental pain stimulation and during pain relief.
Time frame: Through study completion, an average of 6 months
Blood pressure variability (mmHg)
Changes in continuous blood pressure measurement averages during experimental pain stimulation and during pain relief..
Time frame: Through study completion, an average of 6 months
Sympathetic Skin Response (V)
Amplitude of Sympathetic skin response during pain stimulation and relief respectively.
Time frame: Through study completion, an average of 6 months
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