Tenofovir Disoproxil Fumarate in the Treatment of Parkinson's Disease

Phase 1RecruitingNCT06356662

The Fourth Affiliated Hospital of Zhejiang University School of Medicine60 enrolled

Overview

To evaluate the efficacy and safety of tenofovir disoproxil fumarate in the treatment of Parkinson's disease. The changes of motor symptoms and the occurrence of adverse reactions in early Parkinson's disease patients who took tenofovir disoproxil fumarate and did not take Tenofovir disoproxil fumarate at different time points were compared.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Parkinson Disease

Interventions

Tenofovir Disoproxil FumarateDRUG

take tenofovir disoproxil fumarate 300mg/d

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1: Parkinson's disease: Hoehn Yahr= 1 to 2.5 2: MMSE score≥24 Exclusion Criteria: * 1: essential tremor, stroke, epilepsy and other well-defined neurological disorders 2: Or have received deep brain stimulation and other brain surgery 3: Abnormal liver and kidney function 4: Infected with chronic hepatitis B or AIDS (HIV-1 infection) 5: Severe depression, schizophrenia, other psychiatric disorders or drug dependence 6: Other serious physical diseases such as heart, lung, liver, kidney disease, blood disease and malignant tumor 7: Pregnant or lactating women and seniors over 65 years of age 8: Allergy or other contraindications to the investigational drug

Locations (1)

Guohua Zhao

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

UPDRS III（Unified Parkinson's Disease Rating Scale part 3）

score：0-132，higher scores mean a worse outcome

Time frame: 1 month、3 month

Secondary Outcomes

Non-Motor Symptom Scale（NMSS）

score：0-360，higher scores mean a worse outcome

Time frame: 1 month、3 month

creatinine(μmoI/L)

blood biochemistry test，normal\<97μmoI/L

Time frame: 1 month、3 month

Data from ClinicalTrials.gov

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