To evaluate the association between time from PCI to cancer surgery and cardiovascular and oncologic outcomes in early-stage cancer patients, A retrospective, population-based cohort study was conducted using data from the Korean National Health Insurance Service (K-NHIS) database.
Early-stage-cancer patients with a history of PCI who underwent cancer surgery (N = 3621) were included. The patients were divided into two groups based on the time between the dates of PCI and cancer surgery (\<12 months and ≥12 months). Patients were stratified into early-surgery and late-surgery, defined as patients who underwent surgery ≥1 and \<1 month after cancer diagnosis. Outcomes included bleeding, spontaneous myocardial infarction (MI), repeat revascularization, cancer recurrence, and death.
Study Type
OBSERVATIONAL
Enrollment
3,621
Occurence of Bleeding
Bleeding requiring transfusion was defined by the transfusion codes (X2021, X2022, X2031, X2032, X2091, X2092, X2111, X2112, X2131, X2132).
Time frame: up to 5 years
Occurence of Spontaneous myocardial infarction
Spontaneous myocardial infarction (MI) was defined as hospitalization for MI (ICD-10 codes I21 and I22)
Time frame: up to 5 years
Occurence of Repeat revascularization
Repeat revascularization was defined as the presence of a procedure code after cancer surgery.
Time frame: up to 5 years
Occurence of Cancer recurrence
Cancer recurrence was defined as the presence of chemotherapy and/or radiation therapy that began more than 6 months after surgery completion.
Time frame: up to 5 years
Occurence of All cause death
Vital status was obtained from death certification collected by Statistics Korea at the Ministry of Strategy and Finance of South Korea.
Time frame: up to 5 years
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