The Study of Lithogenesis Processes in Patients With Non-alcoholic Fatty Liver Disease (NAFLD)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS42 enrolled

Overview

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, ranging from pure steatosis to non-alcoholic steatohepatitis and ultimately to liver cirrhosis. In order to study the association between NAFLD and nephrolithiasis while minimizing the confounding effect of metabolic syndrome, we investigated the impact of different degrees of NAFLD severity on potential risk factors for stone formation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

NAFLD Urinary Lithiasis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * subject \>= 18 years old * able to sign the ICF * Liver biopsy with report compatible with NAFLD Exclusion Criteria: * alchol use \> 20g/die * other causes of liver disease * active neoplasm

Locations (1)

Fondazione Policlinico A.Gemelli IRCCS

Roma, Italy

Outcomes

Primary Outcomes

the analysis of the correlation between the degree of severity of NAFLD And urinary lithogenic profilecharacterized by reduced urinary magnesium and altered urinary ammonium excretion.

Time frame: 15 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.