Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials

National Taiwan University Hospital10 enrolled

Overview

This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the ventilator out of training. After obtaining the explanatory consent, they will undergo continuous complete Before and after spontaneous breathing training, collect various relevant physiological data of lung volume and ventilation perfusion distribution, and analyze and predict the correlation of ventilator detachment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

High Flow Oxygen Therapy

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Be at least 20 years old, have undergone tracheotomy, have been using a ventilator for at least 10 days, and have stable vital signs. Exclusion Criteria: * Age \<20 years * The oxygen concentration (FiO2) provided by the respirator exceeds 60% * pregnant * Blood pressure-systolic blood pressure below 70 mmHg * Heartbeat is lower than 50/min or higher than 160/min * Respiration rate is higher than 50/min * Lack of voluntary breathing

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

ventilation perfusion distribution measurement

1. Within 2 hours before starting the whole day of ATC, start measuring lung volume and ventilation perfusion distribution in SIMV+PS mode. 2. Start the 72-hour ATC mode, measure once within 2 hours; measure again after 24 hours. 3. Within 2 hours before and after the completion of the 72-hour ATC conversion to the 24-hour tracheostomy tube high flow oxygen, one measurement is made. 4. Measure once within 2 hours before and after the completion of 24-hour high-flow oxygen conversion to 5 consecutive days of spontaneous breathing training. 5. After the use of high flow oxygen starts, measure it every 24 hours until the 5th day.

Time frame: 16 weeks