The proposed research is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in muscle strength, volume, fatigue resistance, and mobility in older adults after daily consumption of 12g of linoleic acid-rich oil.
Study Objectives 1. To assess the effect of linoleic acid supplementation on muscle strength, muscle volume, fatigue- resistance, and physical mobility. 2. To quantify the impact of linoleic acid supplementation on cardiolipin species and mitochondrial function in skeletal muscle of older adults
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
66
Two food products containing 6g of high linoleic safflower oil each will be consumed each day for a total of 12g daily
Two food products containing 6g of high oleic safflower oil each will be consumed each day for a total of 12g daily
The Ohio State University
Columbus, Ohio, United States
RECRUITINGChanges is leg extensor muscle strength
To determine the impact of high linoleic safflower oil on isokinetic leg extensor muscle strength through isokinetic dynamometer
Time frame: Week 0 and Week 24
Changes in quadriceps muscle volume
To determine the impact of high linoleic safflower oil on quadriceps muscle volume through MRI
Time frame: Week 0 and Week 24
Change in maximum leg press strength
To determine the impact of high linoleic safflower oil on maximum leg press strength using leg press machine
Time frame: Week 0 and Week 24
Change in leg fatiguability
To determine the impact of high linoleic safflower oil on muscle fatiguability through isokinetic dynamometer
Time frame: Week 0 and Week 24
Change in muscle mitochondria function
To determine the impact of high linoleic safflower oil on muscle and peripheral blood mononuclear cell mitochondria oxygen consumption rate using the Oroboros instrument
Time frame: Week 0 and Week 24
Changes in cardiolipin species
To determine the impact of high linoleic safflower oil on muscle and peripheral blood mononuclear cell cardiolipin species measured using electrospray ionization-mass spectrometry coupled to high-performance liquid chromatography.
Time frame: Week 0 and Week 24
Changes in grip strength
To determine the impact of high linoleic safflower oil on grip strength measured using hand dynamometer.
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Time frame: Week 0 and Week 24
Changes in gait speed
To determine the impact of high linoleic safflower oil on gait speed measured by timing a 400-meter walk.
Time frame: Week 0 and Week 24
Changes in chair rise time
To determine the impact of high linoleic safflower oil on chair rise time measured by timing rise from a seated position five times.
Time frame: Week 0 and Week 24
Changes in stair climb power
To determine the impact of high linoleic safflower oil on stair climb time measured by timing the completion of climbing 1 flight of stairs
Time frame: Week 0 and Week 24
Change in short physical performance battery score
To determine the impact of high linoleic safflower oil on short physical performance battery short score which is calculated by measured by measuring time it takes to walk 4 meters, rise from a chair 5 times and the ability to balance in 3 standing positions for 10 seconds each. Scores range from 0 (predicts for worst physical performance) to 12 (predicts for best physical performance)
Time frame: Week 0 and Week 24
change in blood fatty acids
To determine the impact of high linoleic safflower oil on changes in blood fatty acids using gas chromatography
Time frame: Week 0 and Week 24