evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.
The signs and symptoms of the oral lichen planus lesion. 2-The associated oral symptoms. 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
Alazhar university ,faculty of Dental Medicine
Asyut, Egypt
to assess a visual analog scale (VAS)of the oral lichen planus lesion
qualitative
Time frame: baseline, 1, 3 and 6 months after treatment
to assess The associated Oral Disease Severity Score 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis
qualitative ,and quantitiave
Time frame: baseline, 1, 3 and 6 months after treatment
Biochemical evaluation of salivary Glutathione level using (ELISA)
Quantity
Time frame: baseline, 1, 3 months after treatment
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RCT