A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Inclusion Criteria: 1. Healthy, non-smoking males and females, aged 18-55 years of age, with BMI between 18.0 and 32.0 kg/m2 inclusive. 2. In good health, determined by no clinically significant findings from medical history and evaluations at screening and check-in as assessed by the investigator. 3. Females of non-childbearing potential, males who agree to a highly effective method of contraception from first dose through 3 months after end of study visit. 4. Participants who are able to swallow tablets and capsules. 5. Participants who are capable and willing of giving signed informed consent. Exclusion Criteria: 1. Participants with significant medical history or clinical manifestation of any medical condition, disease or disorder, as determined by the investigator. 2. History of significant hypersensitivity, intolerance, or allergy to itraconazole or any of the excipients or to medicinal products with similar chemical structures, food or other substance. 3. History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs. 4. Participant has blood pressure \>140 mmHg systolic or \>90 mmHg diastolic at screening or Day -1. 5. Prolonged QT interval corrected for heart rate using Fridericia's correction \>450 ms for males and \>470 ms for females at screening. 6. Positive hepatitis panel and/or positive human immunodeficiency virus test. 7. Abnormalities in liver function test ALT or AST \>1.5 × upper limit of normal. 8. Administration of any vaccine including coronavirus disease 2019 vaccine in the past 14 days prior to check-in. 9. Use or intend to use any medications/products known to alter drug absorption, metabolism, or elimination processes, including St. John's wort, within 30 days prior to check-in. 10. Use or intend to use any prescription medications/products or any nonprescription medications/products within 14 days prior to check-in. 11. Participation in a clinical study involving last administration of an investigational drug (new chemical entity) in the past 30 days prior to dosing, or within 5 half-lives of the IMP, whichever is longer, or have previously received PC14586. 12. Participant has a history of alcohol or drug/chemical abuse within 2 years prior to check-in and/or is unwilling to avoid use of caffeine or alcohol or caffeine-containing foods or alcohol-containing foods, medications, or beverages, within 48 hours prior to check-in until the follow up visit. 13. Use of tobacco- or nicotine-containing products (cigarettes, snuff, chewing tobacco, cigars, pipes, vaporizer, or nicotine-replacement products such as nicotine chewing gum and nicotine patches) within 3 months prior to check-in, or positive cotinine at screening or check-in. 14. Participants with a germline TP53 Y220C mutation at Screening.