Evaluation of Neuromuscular Morphometry of the Vaginal Wall

Gaziosmanpasa Research and Education Hospital62 enrolled

Overview

In this prospective study, women aged between 40 and 75 years who had not undergone any vaginal surgery and had not undergone any abdominal prolapse surgery were included. Thirty-one women diagnosed with rectocele on examination were included in the study group. Thirty-one patients who underwent vaginal intervention and hysterectomy for reasons other than rectocele (colposcopy, conization, etc.) without anterior or posterior wall prolapse were included in the control group.

In this prospective study,who had not undergone any vaginal surgery and had not undergone any abdominal prolapse surgery were included. Thirty-one women diagnosed with rectocele on examination were included in the study group. Thirty-one patients who underwent vaginal intervention and hysterectomy for reasons other than rectocele (colposcopy, conization, etc.) without anterior or posterior wall prolapse were included in the control group. Biopsy material was obtained from the epithelium of the posterior wall of the vagina, including the fascia that fits the Ap point. Immunohistochemical staining with Protein Gene Product 9.5 and smooth muscle α-actin was performed in the pathology laboratory. The epithelial thickness measurement and smooth muscle density parameters obtained with these immunohistochemical stainings were compared between the two groups. The collected data were analyzed using SPSS 23 package program

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pelvic Organ Prolapse

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 40-75 years * Patients operated for prolapse * Patients who did not have prolapse and who would undergo vaginal intervention for other gynecologic reasons were designed to constitute the control group. * who had not undergone any vaginal surgery, had not undergone any abdominal uterine suspension surgery, had posterior wall prolapse, and for whom surgery was planned. Exclusion Criteria: * Patients whose age was not suitable * who had previously undergone vaginal surgery, who had undergone abdominal surgery and a uterine suspension surgery, who were not suitable for the specified examination conditions * who had undergone rectocele surgery, urinary incontinence, or bladder surgery

Locations (1)

Hakan Timur

Ordu, Turkey (Türkiye)

Outcomes

Primary Outcomes

epithelial thickness

Biopsy material was obtained from the epithelium of the posterior wall of the vagina, including the fascia that fits the Ap point. Immunohistochemical staining with Protein Gene Product 9.5 and smooth muscle α-actin was performed in the pathology laboratory

Time frame: one year

smooth muscle density

Time frame: one year

Data from ClinicalTrials.gov

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