Effect of Acupuncture on the Microbiota-gut-brain Axis in Crohn's Disease

Inclusion Criteria: 1. 18 ≤ age ≤ 75 years, gender is not limited; 2. Disease in mildly or moderately active stage: 150 ≤ CDAI \< 450 and at least one of the following is met: serum C-reactive protein ≥ 5 mg/L, faecal calreticulin ≥ 250 μg/g, or endoscopic ulceration, or remission stage: CDAI \< 150 and at least one of the following is met: serum C-reactive protein \< 5 mg/L, faecal calreticulin \< 250 μg/g, or endoscopic No ulcers; 3. Not taking or taking the following medications: mesalazine (≤4 g/d and have been taking for ≥1 month), prednisone (≤15 mg/d and have been taking for ≥1 month), and/or azathioprine (≤1 mg/kg/d and have been taking for ≥3 months); 4. Those who have not used biologics within 3 months prior to study entry; 5. Those who have never received acupuncture treatment; 6. Understand, agree to participate in the study and sign an informed consent form. Exclusion Criteria: 1. Patients who have recently prepared for pregnancy or are pregnant or breastfeeding; 2. Patients with severe organic pathology; 3. Patients with confirmed psychosis; 4. Patients who are suffering from multiple diseases at the same time and taking other drugs for a long time which may affect the observation of this clinical trial; 5. Patients with severe extra-intestinal manifestations such as severe skin diseases (e.g., erythema nodosum, gangrenous pyoderma, etc.), ocular lesions (e.g., iritis, uveitis, etc.), and thromboembolic diseases; 6. Those with severe intestinal fistulae, abdominal abscesses, intestinal stenosis and intestinal obstruction, perianal lesions (perianal abscesses, etc.), gastrointestinal haemorrhage, intestinal perforation and other complications; 7. Those suffering from short bowel syndrome, those who have undergone abdominal or gastrointestinal surgery within the last six months; 8. Those who are unable to perform acupuncture due to the presence of skin diseases or defects in the area selected for acupuncture.