To assess the effect of Dexmedetomidine on serum Tau-217 protein and its relation to the incidence and severity of postoperative cognitive dysfunction in elderly patients undergoing major surgery under general anesthesia.
to assess the effect of dexmedetomidine on serum Tau-217 protein through measuring serum Tau-217 protein preoperative and postoperative period and comparing the 2 measurements , assessing the cognitive dysfunction in the elderly patients and comparing the correlation between the cognitive dysfunction with serum tau-217 level also assessing the neuroprotective effect of dexmedetomidine on postoperative cognitive dysfunction and its relation with serum Tau-217 level.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
QUADRUPLE
Enrollment
94
dexmedetomidine effect in preventing postoperative cognitive dysfunction on elderly patients undergoing major surgery guided with serum Tau-217 protein.
normal saline will be administrated in placebo group
Arwa Essam
Minya, Egypt
RECRUITINGthe effect of dexmedetomidine on serum Tau-217 protein value.
estimation of the effect of dexmedetomidine on serum Tau-217 protein in postoperative period.
Time frame: 2 years
to evaluate the postoperative cognitive dysfunction using Mini-Mental State Scale in both the placebo and dexmedetomidine group.
evaluation of the postoperative cognitive dysfunction by Mini Mental State Scale as \>25 is recorded normal while less than \<24 is positive for cognitive dysfunction.
Time frame: 2 years
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