Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology

Fudan University36 enrolled

Overview

This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list. Then genes analyzed by Gene Ontology, protein interactions, and signaling pathway enrichment using the expression matrix.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Incisional Hernia Extracellular Matrix Alteration

Interventions

Transcriptomic analysisDIAGNOSTIC_TEST

high-throughput sequencing technology

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1.18 to 75 years 2.diagnosed with incisional hernia 3.normal tumour markers 4.elective surgery patients. Exclusion Criteria: 1. patients with vital organ failure (heart liver, lung, kidney and others) 2. malignant tumors not been completely relieved by active treatment, 3. patients who have psychiatric diseases or comprehension disorders. 4. patients with metabolic disease involving connective tissue collagen.

Locations (1)

Hua Dong Hospital Affiliated to Fu Dan University

Shanghai, China

Outcomes

Primary Outcomes

the gene expression list

Time frame: 2023.3-2023.9

Data from ClinicalTrials.gov

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