Result of tDCS in ASD Children With Comorbidities Like PANDAS, Rare Genetic Diseases or Autoimmune Disorders

Phase 1Enrolling By InvitationNCT06368726

Spanish Foundation for Neurometrics Development180 enrolled

Overview

Results of the application of 100 sessions of tDCS for 12 months in children between 6 and 11 years old with autism spectrum disorder with rare diseases, genetic problems or PANDAS

tDCS will be applied to 90 children diagnosed with ASD with Mu activity in one of their two temporal lobes and to another 90 children tDCS will not be applied but rather conventional treatments such as the Denver method, etc., in addition to collecting their electroencephalograms in eyes open condition, evoked potentials will be performed. with Mismatch Negativity paradigm to calculate the P300 wave every 25 sessions with a rest of 5-6 weeks between every 25 sessions and the changes in voltage and frequency of the EEG will be analysed using FFT \& PSD, as well as the latencies and amplitudes of its P300 wave.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

180

Conditions

Attention Visual Perceptual Weakness Social Behavior Fluency Disorder EEG With Periodic Abnormalities

Interventions

tDCS or Transcranial Direct Current StimulationDEVICE

We use weak currents applied over the child's scalp over 30 minutes twice a week during 100 days

RisperidoneDRUG

Risperidone Risperidone according to child's weighs

Eligibility

Sex: ALLMin age: 6 YearsMax age: 11 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 7 and 15 years old * Diagnosis: PDD, ASD or PANDAS * Have genetic alterations with geneticist reports like: mutation, random mating between organisms, random fertilization or crossing over (or recombination) between chromatids of homologous chromosomes during meiosis. * Natural birth without caesarean or complications * Normal Pregnancy Exclusion Criteria: * Head Trauma * Brain Injuries like meningitis or encephalitis, including SaRS, Herpes or MERS infections * Epilepsy * Rare Diseases with Auto-Immune Disease * Rare diseases with Endocrinology problems * Fever or Biochemical problems in the First Blood Test (First Visit) * Vaccines Reactions

Locations (1)

New Remedies

Liverpool, Merseyside, United Kingdom

Outcomes

Primary Outcomes

FFT

Change in Voltage for every frequency band

Time frame: 12 months

Power Density Spectrum Changes or PSD

Amplitude of the PSD

Time frame: 12 Months

ERP MMN changes

Changes in P300 wave amplitude

Time frame: 12 months

ERP MMN Changes

Changes in P300 wave latency

Time frame: 12 Monts

Secondary Outcomes

Attention

Using ATTC scale average Scale

Time frame: 12 months

Social Skills

We used SSRS Scale Total Teacher Scale

Time frame: 12 months

Language

GhostBusters Res Spoken Language and Listening Average Score from 40 Cards

Time frame: 12 months

Visual Contact

P200 wave amplitude in occipital lobe

Time frame: 12 months

Data from ClinicalTrials.gov

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