This is an observational (non-interventional) prospective study, carried out in drug-naïve outpatients who start a treatment with escitalopram, fluoxetine, sertraline or quetiapine. Five blood samples are collected (i.e. before initiating the drug, and then after 1, 2, 4 and 8 weeks of treatment). It does not affect the choice or the treatment dose. The primary objective of this study is to measure the association between the EDIT-B® editing signature and response to pharmacological treatment in drug-naïve patients. Results of this research could provide an aid to early diagnosis, optimize pharmacological treatment and guide clinical practice towards individualized treatment.
Study Type
OBSERVATIONAL
Enrollment
200
Les Toises - Psychiatry and Psychotherapy Center
Lausanne, Switzerland
RECRUITINGpsychiatric symptomatology
self- and hetero-questionnaire psychiatric scales
Time frame: At baseline, 1,2,4,8 weeks
EDIT-B profiling
Measurement of RNA editing over time
Time frame: At baseline, 1,2,4,8 weeks
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