Phase 2 study to assess the efficacy of topically administered eyedrops of INV-102 during 4-week repeat dosing in subjects with moderate to severe dry eye disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
109
iuvo BioScience
Rush, New York, United States
Change from Baseline in corneal fluorescein staining total score on the National Eye Institute (NEI)/Industry scale
Corneal fluorescein staining assessment will be performed using the NEI grading system to score each of 5 corneal zones (central, superior, lateral, medial, inferior) on a 0 to 3 scale (with a total score of 0 to 15). Higher scores indicate more corneal damage.
Time frame: Baseline to Day 29
Percentage of eyes with complete clearing of central corneal fluorescein staining
Time frame: Baseline to Day 29
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