Lifestyle Intervention for Obstructive Sleep Apnea in Women

Oxygen desaturation index (ODI)

Change in the number of oxygen desaturations greater than or equal to 4%/h measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Oxygen saturation (SaO2) mean

Change in the average of oxygen saturation measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Oxygen saturation (SaO2) nadir

Minimum oxygen saturation measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Sleep efficiency

Change in the total sleep time/total time in bed measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Light sleep (N1 and N2 stages)

Change in the percentage of light sleep (N1 and N2 stages) measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Deep sleep (N3 stage)

Change in the percentage of deep sleep (N3 stage) measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Rapid eye movement (REM) sleep

Change in the percentage of REM sleep measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Excessive daytime sleepiness (EDS)

Change in the difficulty in maintaining a desired level of wakefulness, measured by the Epworth sleepiness scale (ESS) from baseline to post-intervention. ESS is a 4-point scale (0 = no chance of dozing, 1 = slight chance of dozing, 2 = moderate chance of dozing, 3 = high chance of dozing) that measures the usual chances of dozing off or falling asleep while engaged in eight different activities. An ESS total score from 0 to 9 is considered to be normal while an ESS total score \> 9 indicates high daytime sleepiness.

Time frame: Post-intervention (2 months)

Sleep Quality

Change in Pittsburgh Sleep Quality Index (PSQI) from baseline to post-intervention. This scale includes a total of 19 self-rated items combined to form seven component scores i.e., subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction), each of which has a range of 0-3 points. The sum of these seven PSQI component scores is considered to obtain a global PSQI score (ranging from 0-21), with higher scores indicating poorer sleep quality.

Time frame: Post-intervention (2 months)

Wake After Sleep Onset (WASO)

Change in Wake After Sleep Onset (WASO; minutes) measured by a respiratory polygraphy, from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Fat mass (kg)

Change in fat mass (kg) measured by a whole-body densitometry using dual-energy X-ray absorptiometry (DEXA), from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Visceral adipose tisue (g)

Change in visceral adipose tisue (g) measured by a whole-body densitometry using dual-energy X-ray absorptiometry (DEXA), from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Body weight (kg)

Change in body weight (kg) measured by a scale from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Neck circumference (cm)

Change in neck circumference (cm) measured by a tape measure from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Chest circumference (cm)

Change in chest circumference (cm) measured by a tape measure from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Waist circumference (cm)

Change in waist circumference (cm) measured by a tape measure from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Mean blood pressure (mm HG)

Change in mean blood pressure (mm HG) measured by a blood pressure cuff from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Plasma glucose (mg/dL)

Change in plasma glucose (mg/dL) measured by a blood test from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Change in total cholesterol (mg/dL) from baseline to post-intervention

Change in total cholesterol (mg/dL) measured by a blood test from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)

Change in total triglycerides (mg/dL) from baseline to post-intervention

Change in total triglycerides (mg/dL) measured by a blood test from baseline (week 0) to post-intervention (2 months)

Time frame: Post-intervention (2 months)