NNC0519-0130 is a new medicine to improve the treatment options for people living with type 2 diabetes and people with overweight. In this study one dose of NNC0519-0130 will be given and blood levels of NNC0519-0130 will be compared between people with reduced kidney function and people with normal kidney function. The study will last up to 52 days including a screening phase of up to 28 days prior to dosing.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
36
NNC0519-0130 will be administered subcutaneously.
Charité Research Organisation GmbH
Berlin, Germany
Area under the curve (AUC)0-∞,NNC0519-0130,SD: Area under the NNC0519-0130 plasma concentration-time curve after a single dose in participants with normal function, and mild, moderate and severe impairment
Measured in hours\* nanomoles per litre (h\*nmol/L).
Time frame: From baseline (visit 2, day 1) until completion of the end-of-study visit (visit 9, day 22)
Maximum concentration (Cmax),NNC0519-0130,SD: Maximum observed NNC0519-0130 plasma concentration after a single dose in participants with normal function, and mild, moderate and severe impairment
Measured in nanomoles per litre (nmol/L).
Time frame: From baseline (visit 2, day 1) until completion of the end-of-study visit (visit 9, day 22)
AUC0-∞,NNC0519-0130,SD: Area under the NNC0519-0130 plasma concentration-time curve after a single dose in participants with kidney failure
Measured in hours\* nanomoles per litre (h\*nmol/L).
Time frame: From baseline (visit 2, day 1) until completion of the end-of-study visit (visit 9, day 22)
Cmax,NNC0519-0130,SD: Maximum observed NNC0519-0130 plasma concentration after a single dose in participants with kidney failure
Measured in nanomoles per litre (nmol/L).
Time frame: From baseline (visit 2, day 1) until completion of the end-of-study visit (visit 9, day 22)
Number of adverse events
Number of events.
Time frame: From time of dosing (visit 2, day 1) until end of study (visit 9, day 22)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.