The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
32
Inhalation of 50 uL of a natural odour via nasal septum mini-inhaler.
Inhalation of 50 uL of Placebo via nasal septum mini-inhaler.
University Hospital Basel
Basel, Switzerland
NOT_YET_RECRUITINGUniversity Hospital of Basel
Basel, Switzerland
RECRUITINGDetection of a natural odour in human CSF
Detection of a natural odour in human CSF within 30 min following end of an 15 min olfactory stimulation thereof compared to placebo. The presence of the Verum (natural odour) will be assessed via Gas Chromatography-Mass Spectrometry. This will be analyzed using a binary logistic regression model to determine the odds ratio of detecting a natural odour in the CSF post-stimulation. The model will account for variables such as age, sex, and BMI category (obese vs. lean). The significance level will be set at p \< 0.05.
Time frame: 1 time assessment at baseline
Abundance of a natural odour in human CSF of obese versus lean participants
Detection of a natural odour in human CSF of obese versus lean participants within 30 min following end of an 15 min olfactory stimulation with a natural odour. Titration of the natural odour will be done via Gas Chromatography-Mass Spectrometry.
Time frame: 1 time assessment at baseline
Change in abundance of a natural odour in blood before and after olfactory stimulation in relation to abundance in human CSF.
Change in abundance of a natural odour in blood before and after end (max 30 min) of an olfactory stimulation for 15 min in relation to abundance in human CSF. Titration of the natural odour in CSF and blood samples will be done via Gas Chromatography-Mass Spectrometry.
Time frame: 2 times assessment at baseline (immediately before olfactory stimulation and within 30 min following end of olfactory stimulation)
Change in abundance of a natural odour in blood before and after olfactory stimulation in obese as compared to lean participants.
Change in abundance of a natural odour in blood before and after end (max 30 min) of an olfactory stimulation for 15 min in obese as compared to lean participants. Titration of a natural odour in blood samples will be done via Gas Chromatography-Mass Spectrometry.
Time frame: 2 times assessment at baseline (immediately before olfactory stimulation and within 30 min following end of olfactory stimulation)
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