The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women. The main questions it aims to answer are: * Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone? * Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone? Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will be given to both groups. Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed.
Young, healthy, active men and women will ingest 30 grams of hydrolyzed collagen or a calorie matched beverage (maltodextrin) alongside vitamin C prior to performing high-intensity resistance training 2 - 3 times per week for 10 weeks. The aim of this study is to investigate the effect of combining hydrolyzed collagen supplementation with resistance training in young men and women. If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance. The experimental design and measurements will be the same in the Arm 1 and Arm 2 but the differences will be sex where participants in Arm 1 will be healthy young men while participants in Arm 2 will be healthy young women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
23
Participants in this intervention will be healthy young men. The information of nutritional supplements is below. Hydrolyzed collagen: 30 grams unflavored hydrolysed collagen (HC) (Myprotein, Cheshire, UK) 30.5 grams unflavored maltodextrin (Myprotein, Cheshire, UK) 50 milligrams vitamin C powder (Holland and Barrett Retail Limited, Warwickshire, UK) 3 grams non-caloric sweetener (Truvia®, SilverSpoon, London, UK)
Participants in this intervention will be healthy young women. The same nutritional supplements in Arm 1 wil be used in Arm 2.
Research Institute for Sport and Exercise Sciences
Liverpool, Merseyside, United Kingdom
Maximal knee extensor (quadriceps) muscle strength
Using isokinetic dynamometer, knee extensor maximal isometric voluntary contraction torque (in Newton meters) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for assessments)
Maximal knee flexor (hamstring) muscle strength
Using an isokinetic dynamometer, knee flexor maximal isometric voluntary contraction torque (in Newton meters) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Patellar tendon cross-sectional area
Using ultrasonography, patellar tendon cross-sectional area (in millimeters squared) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Patellar tendon stiffness
Using ultrasonography, patellar tendon stiffness (in Newtons per millimeter) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Vastus lateralis (VL) muscle size
Using ultrasonography, the VL anatomical cross-sectional area (in centimeters squared) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Vastus lateralis (VL) muscle fascicle length
Using ultrasonography, VL muscle fascicle length (in millimeters) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Vastus lateralis (VL) muscle fascicle pennation angle
Using ultrasonography, VL muscle fascicle pennation angle (in degrees) will be measured.
Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
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