The study aims to determine how expression levels of biomarkers for peripheral arterial disease change over time in response to exercise therapy, surgical or endovascular intervention, and whether they can be used to predict disease progression.
Several studies have identified markers in the blood (called biomarkers) that are associated with peripheral arterial disease, or clogging up of the blood supply to the leg. There is little understanding however regarding how these respond to intervention, and how they are related to walking distance. This study will increase the understanding of the relationship between peripheral arterial disease state and biomarker expression and enable us to work towards the development of new targets for treatment. Participants will be invited to undertake questionnaires and dedicated walking tests alongside regular blood tests to check their biomarker levels. These will be undertaken on a regular basis so the investigators can see what happens over time, such as after a surgical procedure, and see if these markers go back towards normal following intervention.
Study Type
OBSERVATIONAL
Enrollment
100
Correlation between PAD biomarker levels and walking distance.
The correlation between PAD biomarker levels and walking distance.
Time frame: Baseline
Change in PAD biomarker levels following exercise therapy.
To investigate the change in PAD biomarker levels following exercise therapy.
Time frame: 6 months up to 2 years
Change in PAD biomarker levels following endovascular intervention
To investigate the change in PAD biomarker levels following endovascular intervention
Time frame: 48 hours
To determine whether biomarker levels normalise with improved walking distance.
Change in biomarker levels in participants with improved walking distance compared to particicpants with static or deteriorating walking distance at 6 months.
Time frame: 2 years
To determine whether biomarker levels can be used as a predictor of restenosis, occlusion or reintervention following endovascular intervention.
Compare the change in biomarkers levels pre and post angioplasty between participants requiring reintervention or occlusion, and those not requiring re-intervention or occlusion.
Time frame: 2 years
Levels of biomarkers and (Major Adverse Cardiovascular Events).
The association between levels of biomarkers and (Major Adverse Cardiovascular Events).
Time frame: 2 years
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