The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
210
tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)
tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)
tACS applied to frontal areas at 4-7 Hz
tRNS applied to occipital brain regions
tRNS applied to frontal brain regions
tACS is activated only for 30 seconds and then turned off, thus resulting ineffective
tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective
Università Vita-Salute San Raffaele
Milan, Italy
RECRUITINGBehavioral measures
To study if tACS or tRNS delivered in different brain networks can modulate the learning of statistical regularities in the context of visual perception we will evaluate the following behavioral measures recorded in a computerized visual perception task: hit rate, miss, false alarms, correct rejections. These behavioral measures will allow to derive measures of sensitivity (d') and response criterion (Beta and C), according to the theoretical framework of the Signal Detection Theory (SDT).
Time frame: During the procedure
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