HAIC Combined With PD-L1 Plus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma After Immunotherapy Failure

Inclusion Criteria: * Advanced HCC confirmed by imaging or histopathological examination based on biopsy specimens and/or surgical pathology; * Patients who have failed ≥1 line of PD-1/PD-L1 immune checkpoint inhibitor therapy; * Imaging diagnosis with at least one measurable lesion according to the Response Evaluation Criteria in Solid Tumors (RECIST1.1); * Expected survival period ≥3 months; * ECOG performance status of 0-1; * Child-Pugh score of grade A (i.e., a score of 5 to 6); * Adequate organ and bone marrow function; * Male participants and women of childbearing potential must use contraception from the start of the first dose to 3 months after the last dose; * Expected good compliance and ability to comply with the study requirements. Exclusion Criteria: * Previous history of immunotherapy with any of the following: 1. Any grade 3 or higher immune-related adverse events (irAEs); 2. Any unresolved grade 2 irAEs; 3. Any toxicity resulting in permanent discontinuation of prior anti-PD-1/PD-L1 immunotherapy; 4. Patients assessed as having progressed within ≤3 months during prior immunotherapy. * Previous treatment with Regorafenib; * Known allergy to the study drug or any of its excipients; * Received any of the following treatments or medications prior to the first study treatment: 1. Major surgery within 28 days prior to treatment initiation (diagnostic tissue biopsy is allowed). 2. Use of immunosuppressive medications within 7 days prior to treatment initiation, excluding nasal and inhaled corticosteroids or physiological doses of systemic corticosteroids (i.e., not exceeding 10 mg/day of prednisone or its equivalent). 3. Receipt of immunomodulatory drugs (such as thymosin, interferon, interleukins) within 3 weeks prior to treatment initiation. 4. Receipt of attenuated live vaccines within 28 days prior to treatment initiation. 5. Receipt of other systemic anticancer therapy within 28 days prior to treatment initiation. * Known uncontrollable or symptomatic active central nervous system (CNS) metastases; * Diagnosis of other active malignancies within 2 years prior to study entry, except for locally treated and cured basal cell carcinoma or squamous cell carcinoma of the skin, superficial bladder cancer, cervical carcinoma in situ, ductal carcinoma in situ of the breast, and papillary thyroid cancer. * Presence of any active autoimmune disease or history of autoimmune disease with anticipated recurrence; * Human immunodeficiency virus (HIV) infection or known AIDS, untreated active hepatitis, HBV-DNA \>2000 IU/ml with abnormal liver function; hepatitis C or combined HBV and HCV co-infection; * Within 6 months prior to study entry, experienced: * Myocardial infarction, severe/unstable angina, NYHA class 2 or higher heart failure, clinically significant ventricular or supraventricular arrhythmias requiring clinical intervention; poorly controlled hypertension; * History of gastrointestinal bleeding or tendency to gastrointestinal bleeding within the past 6 months; * Urine protein ≥++ or 24-hour urine protein \>1.0g; * Inability to swallow study drugs, presence of chronic diarrhea (including but not limited to irritable bowel syndrome, Crohn's disease, ulcerative colitis), and factors affecting drug intake and absorption such as intestinal obstruction. * Pregnant or lactating women, and women of childbearing potential unwilling to adopt effective contraceptive measures; * Other patients deemed unsuitable for participation in this study by the investigator.