A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults

Inclusion Criteria: * Healthy male or female subjects 18 to 64 (inclusive at screening) years of age. * Women of childbearing potential and all males must practice effective contraception during the study and be willing and able to continue contraception until end of study. * Signed informed consent form prior to any study-related procedures. Exclusion Criteria: * Active smoker or history of smoking \> 5 pack years. * Upper or lower respiratory tract infection or febrile illness * Presence (at screening) of serum RV-39 neutralizing antibody titer at greater than one in four (1:4) dilution. * Nasopharyngeal swab indicative for Influenza or SARS-CoV2 infection by rapid antigen test at baseline. * Prior inoculation with a virus from the same virus family as the challenge virus. * Any anatomic or neurologic abnormality impairing the gag reflex, or associated with an increased risk of aspiration, or any abnormality significantly altering the anatomy of the nose or nasopharynx in a substantial way that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge. * Positive Hepatitis B surface antigen (HBsAg), Hepatitis C virus antibody (HCV Ab), or human immunodeficiency virus antibody (HIV Ab) at screening. * Any confirmed or suspected disease or condition associated with immune system impairment, including auto-immune diseases, asplenia or recurrent severe infections. * Active allergic rhinitis or hay fever. * Medical history or active asthma or chronic obstructive pulmonary disease (COPD) or any other pulmonary disease deemed by the investigator to increase the risk of participating in the study. * Active nasal disease, e.g., nasal polyposis, significant septal deviation, chronic rhinosinusitis, etc. * Frequent epistaxis or nasal sinus surgery within 3 months before baseline. * Females: Pregnant, breast-feeding or intentions to become pregnant during the study. * Evidence or history of drug or alcohol abuse. * Positive test for drugs of abuse at screening or prior to study drug administration. * Use of any prescribed or non-prescribed medication (except for contraceptives, paracetamol) within 1 week or less than 5 half-lives (whichever is longer) prior to the first administration of investigational product. * Use of any over the counter cold prophylaxis products including nasal sprays, C-vitamins, zinc or Echinacea within 2 weeks prior to the first administration of investigational product. * Participation in an investigational medical product, vaccine or device study within 3 months or 5 half-lives prior to the study period (whichever is longer), or more than 4 times in the past year. * Hypersensitivity/allergy to any of the investigational product ingredients. * Individuals with close contact to at risk patient group (infants less than 3 years, the extremely elderly \>80 years or infirm, pregnant women, patients with severe lung disease(e.g., asthma/cystic fibrosis (CF)/COPD), patients with primary or secondary immunodeficiencies or ongoing immunosuppressive therapy). * Any clinically relevant abnormal history, physical finding, 12-lead safety ECG, vital signs, laboratory value at screening or any known factor that could interfere with the objectives of the trial or the safety of the volunteer. In the case of uncertain or questionable results, tests performed during screening may be repeated before inclusion to confirm eligibility or judged to be clinically irrelevant.