Sinonasal Risk Factors for Occurrence of Unilateral Versus Bilateral Allergic Fungal Rhinosinusitis .

N/ANot Yet RecruitingNCT06376071

Assiut University76 enrolled

Overview

This study aims to assess Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhino sinusitis regarding:: 1. anatomical variations and correlate radiological finding with intraoperative finding. 2. other associated factors like demographic ,environmental, immunological and climatic risk factors .

Introduction Allergic fungal rhinosinusitis (AFRS) is a subtype of CRS with nasal polyposis (CRSwNP) that is characterized by eosinophilic mucin within expanded sinus cavities and immunoglobulin E (IgE)-mediated type 1 hypersensitivity to fungal elements. This noninvasive disease process typically affects immunocompetent, younger patients in geographic regions with warm temperatures and high humidity, which facilitate fungal proliferation. AFRS has a worldwide distribution pattern with varying prevalence. AFRS is presented in variable rates in different climatic, socioeconomic, and geographic factors. The disease prevalence showed predilection toward climatic factors

Study Type

OBSERVATIONAL

Enrollment

Conditions

Allergic Fungal Rhinosinusitis

Interventions

functional endoscopic sinus surgeryDIAGNOSTIC_TEST

functional endoscopic sinus surgery for diagnosis the disease

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: Denovo cases . any Age Any sex. Patients diagnosed with unilateral or bilateral allergic fungal rhino sinusitis, meeting classic Bent and Kuhn criteria for AFRS:(10). Nasal polyposis. Fungi on staining. Eosinophilic mucin without fungal invasion into sinus tissue., Type I hypersensitivity to fungi. Characteristic radiologic findings with soft-tissue differential densities on computed tomographic (CT) scanning Exclusion criteria: Diagnosis of benign or malignant neoplasm of the sinonasal cavity. Prior radiation therapy to the head or neck. Significant prior facial trauma. Autoimmune disorder. Craniofacial anomaly. Fungus ball. Immunodeficiency. Cystic fibrosis. Patients unfit for surgery. Previous nasal surgery or recurrent cases .

Outcomes

Primary Outcomes

Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhinosinusitis

analysis of the risk factors of unilateral versus bilateral allergic fungal rhinosinusitis

Time frame: baseline

Central Contacts

khater nosir sayed, master

CONTACT

01011973180 khatrsnyr289@gmail.com

Data from ClinicalTrials.gov

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