Risk of Aspergillus Infection in Patients With Chronic Lung Disease

Lin Chen209 enrolled

Overview

Large doses of systemic corticosteroids ，severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined.

Patients with chronic lung disease were identified as positive for Aspergillus fumigatus through sputum microscopy. According to diagnostic criteria, patients diagnosed with IPA and CPA and were assigned to the Aspergillosis pneumonia group, while the remaining patients were included in the Aspergillus colonization group. Then,Risk factors for aspergillus pneumonia, invasive pulmonary aspergillus disease, and chronic pulmonary aspergillus disease, such as the use of high-dose corticosteroids, inhaled corticosteroids, and the extent of damage to basic lung structures, were identified by comparing the aspergillus colonization group with the aspergillus infection group.

Study Type

OBSERVATIONAL

Enrollment

209

Conditions

Fungal Infection Lungs

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age : at least 18 years old ; 2. Imageological examination : Patients who complete high-resolution computed tomography (HRCT) images of the chest; 3. Serological examination : Patients who complete serological test results, including serum aspergillus specific IgG antibody, serum aspergillus IgM antibody and GM antigen detection. Exclusion Criteria: 1. immunodeficiency conditions : Patients diagnosed with HIV infection, hematological malignancies, and autoimmune diseases. 2. Critically ill patients : Those who require mechanical ventilation in the ICU and have established various types of cardiopulmonary bypass. 3. Inadequate Clinical Data: Inability to provide reliable diagnostic measurements or insufficient clinical information.

Locations (1)

Sichuan Provincial People's Hospital

Chengdu, Sichuan, China

Outcomes

Primary Outcomes

Descriptive statistical index

Summarize participant characteristics using means and standard deviations for continuous variables and frequencies for categorical variables

Time frame: Information was collected on the day of admission

Independent risk factor for aspergillus pneumonia

Independent risk factors for aspergillus infection were determined by multivariate logistic regression analysis.

Time frame: Statistical analysis was carried out after data collection within one month

The area under ROC curve of risk factors for aspergillus pneumonia

The area under ROC curve (AUC) was used to evaluate the classification effect of the binary classification model among Aspergillus pneumonia group, IPA group and CPA group

Time frame: Statistical analysis was carried out after data collection within two month

Secondary Outcomes

Threshold analysis of aspergillus pneumonia

Specific cut-off values for Aspergillus specific IgG antibody × lung structural injury image score was determined to maximize diagnostic accuracy, focusing on sensitivity, specificity, and Youden index.

Time frame: Statistical analysis was carried out after data collection within two month

Data from ClinicalTrials.gov

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