The goal of this research study is to compare two ultrawide field cameras to the gold standard imaging system to evaluate the back of the eye. The main question it aims to answer is the same results and information can be acquired from all of the cameras for evaluating and monitoring inherited retinal diseases (IRDs). Participants will: * undergo pupillary dilation * have photographs taken of the inside of the eyes using three different cameras
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
50
Spectralis is a scanning laser ophthalmoscope which uses a blue light excitation wavelength of 488nm and a 500nm barrier filter to produce FAF images. Spectralis images 20-55 degrees of the retina.
Optos is an ultrawide field imaging platform which images up to 200 degrees of the retina. It uses both a green-light excitation wavelength of 532nm and a red-light excitation wavelength of 633nm with an emission filter of greater than 540nm to produce FAF images.
Clarus 700 is an ultrawide field imaging system with similar retinal coverage to that of Optos. It uses Broad Line Fundus Imaging to produce blue FAF images at excitation wavelengths of 435-500nm and green FAF images at wavelengths of 500-585nm
Department of Ophthalmology and Visual Sciences
Madison, Wisconsin, United States
RECRUITINGCompare FAF retinal patterns by Clarus and standard Spectralis FAF imaging
Graders will independently measure area of FAF retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices.
Time frame: Up to 2 hours
Compare FAF retinal patterns by Optos and standard Spectralis FAF imaging
Graders will independently measure area of FAF retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices.
Time frame: Up to 2 hours
Compare FAF retinal patterns by Clarus and Optos FAF imaging
Graders will independently measure area of FAF retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices.
Time frame: Up to 2 hours
Compare Spectralis FAF imaging to Spectralis OCT imaging
In participants with clearly defined macular FAF retinal pattern changes, graders will independently measure area of retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices.
Time frame: Up to 2 hours
Prevalence of FAF retinal pattern changes beyond the standard 30 degress in Clarus and Optos ultrawide field images
The presence of FAF retinal pattern changes outside field 2 will be documented from the two ultrawide field imaging devices
Time frame: Up to 2 hours
Prevalence of other autofluorescence abnormalities unique to the IRD across all imaging
The presence of abnormal autofluorescence outside field 2 will be documented from the two ultrawide field imaging devices
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Up to 2 hours