Developmental and Epileptic Encephalopathy (DEE) are a heterogeneous group of neurodevelopmental disorders linked to both epilepsy and its underlying etiology, independently of epileptiform activity. The creation of a database with retrospective follow-up of a large number of patients on a national scale will enable better knowledge of specific biomarkers, and thus a better classification and understanding of the natural evolution of DEE according to their etiology. This will enable better, more personalized therapeutic management of patients, depending on etiology and the presence or absence of these biomarkers. The investigators will also be able to draw up management recommendations, which are currently non-existent.
Study Type
OBSERVATIONAL
Enrollment
400
CHU Amiens
Amiens, France
NOT_YET_RECRUITINGCH Angers
Angers, France
NOT_YET_RECRUITINGChu Besancon
Besançon, France
NOT_YET_RECRUITINGCHU Bordeaux
Bordeaux, France
NOT_YET_RECRUITINGCHRU Brest
Brest, France
NOT_YET_RECRUITINGCHU Clermont-Ferrand
Clermont-Ferrand, France
NOT_YET_RECRUITINGCHU Grenoble
Grenoble, France
NOT_YET_RECRUITINGCHU Lille
Lille, France
NOT_YET_RECRUITINGCHU Limoges
Limoges, France
NOT_YET_RECRUITINGCHU Lyon HCL
Lyon, France
NOT_YET_RECRUITING...and 13 more locations
Identification of diagnostic and early predictive biomarkers of a neurodevelopmental trajectory with epileptic and developmental encephalopathies
This composite outcome includes multiple diagnostic domains (Clinical, biological, radiological, genetic and electroencephalographic variables)
Time frame: Data 2002-2026
Identification of patient subgroups presenting the identified biomarkers
To identify patient subgroups, correlation analyses will be carried out to highlight any common clinical, biological, genetic, radiological and electroencephalographic findings.
Time frame: Data 2002-2026
Assessment of patients' quality of life
The SF-12 questionnaire is used to assess quality of life.
Time frame: Data 2002-2026
Assessment of age-related adaptive behavior
To assess the age of adaptive behavior, the Vineland II scale is the reference test.
Time frame: Data 2002-2026
Assessment of behavioral disorders
The CBCL (Child Behaviour Checklist) questionnaire is the reference test for assessing behavioural problems.
Time frame: Data 2002-2026
Assessment of autism spectrum disorders
The Social Communication Questionnaire (SCQ) will be used to assess autism spectrum disorders.
Time frame: Data 2002-2026
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