The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.
Before surgery, study participants will be asked questions about age, gender, education level, etc. Study participants will also be questioned regarding pancreatic symptoms, as measured on the patient-Reported Outcome Scale in Acute Pancreatitis (including, pain, abdominal distention, eating, bowel movements, nausea and vomiting, thirst, and weakness). Organ dysfunction was defined according to the sequential organ failure assessment (SOFA) score. The SOFA score will be measured at preoperative (T1), postoperative day 1 (T2), postoperative day 3 (T3), postoperative day 7, or at hospital discharge, whichever comes first (T4). Following discharge from the hospital, study participants will be contacted at 1 month, 3 months, 6 months, and 1 year after surgery, and asked to complete a survey about their pancreatic symptoms and survival status after surgery.
Study Type
OBSERVATIONAL
Enrollment
200
Study the dynamic nature of organ dysfunction
West China Hospital, Sichuan University
Chengdu, China, China
RECRUITINGMeasure organ dysfunction change after open necrosectomy with respect to time
Organ dysfunction will be measured using sequential organ failure assessment score scale. The scores range from 0 (normal) to 4(most abnormal) for each organ, with higher scores indicating worse health status
Time frame: up to postoperative day 7, or at hospital discharge, whichever comes first
incidence of a composite of major complications
Major complications were defined as new-onset organ failure (ie, cardiovascular, pulmonary, or renal)
Time frame: up to postoperative day 28
Incidence of ICU mortality
Death occurred in ICU
Time frame: through study completion, an average of 1year
Incidence of hospital mortality
Death occurred in hospital
Time frame: through study completion, an average of 1 year
Incidence of 28-day mortality
Death occurred within 28-day after surgery
Time frame: through study completion, an average of 1 year
Incidence of one year mortality
Death occurred within one year after surgery
Time frame: through study completion, an average of 1 year
ICU length of hospital stay
Determined by the number of days from ICU admittance to discharge from ICU
Time frame: through study completion, an average of 1 year
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Length of hospital stay
Determined by the number of days from admittance to discharge
Time frame: through study completion，an average of 1 year
The pancreatic symptoms score
Pancreatic symptom scores will be measured at preoperative, postoperative day 1, day 2, day 3, day 7, or at hospital discharge, whichever comes first, at 1 month, 3 months, 6 months, and 1 year postoperatively. Both were measured using the Patient-Reported Outcome Scale, which ranges from 0 to 10 for each symptom; The overall range is from 0 to 70, with higher scores indicating higher symptom intensity.
Time frame: up to 1 year
The levels of inflammatory factor CRP
Peripheral blood CRP
Time frame: preoperative, postoperative day 1, day 3 and day 7 or at hospital discharge, whichever came first.
The levels of inflammatory cytokines IL-6
cytokines IL-6
Time frame: preoperative, postoperative day 1, day 3 and day 7 or at hospital discharge, whichever came first.
The levels of inflammatory procalcitonin
procalcitonin was measured at preoperative, postoperative day 1, day 3 and day 7 or at hospital discharge, whichever came first.
Time frame: preoperative, postoperative day 1, day 3 and day 7 or at hospital discharge, whichever came first.