The Efficacy of Radiomics to Predict Tumor Microenvironment Markers and Comprehensive Therapy for Bladder Cancer

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University1,200 enrolled

Overview

The aim of this study was to develop an radiomic model based on CT images to evaluate markers of the bladder cancer microenvironment, such as TSR,TIL, and IP. Secondly, the association of the radiomic model with clinical outcomes and immunotherapy response was investigated.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Bladder Cancer Radiomics Immunotherapy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. At least 18 years of age; 2. Performing TURB-t or RC during 2010-2022; 3. The primary lesion was located in the bladder, and the pathological diagnosis was urothelial carcinoma; 4. Complete clinical information, pathological data, preoperative pelvic enhanced CT and follow-up records; Exclusion Criteria: 1. Patients with distant metastasis; 2. Combined with other malignant tumors or malignant tumor treatment history 3. Malignant tumors of upper urinary tract; 4. Clinical information, pathological data, preoperative pelvic enhanced CT and follow-up records were missing; 5. Other situations in which the researcher considers it inappropriate to participate in this study.

Locations (1)

Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Tumour-infiltrating lymphocytes (TIL)

TILs were evaluated using paraffin-embedded tumour tissue samples stained with H\&E according to established protocols.

Time frame: 1 year

Secondary Outcomes

overall survival

We obtain this data through telephone follow-up and evaluate it according to the date of surgery

Time frame: 1 year

cancer-specific survival

We obtain this data through telephone follow-up and evaluate it according to the date of surgery

Time frame: 1 year

Data from ClinicalTrials.gov

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