This is a 2-part study evaluating the effects of IV administration of NR on healthy adult populations. Study 1 involved all four arms with 37 people. The second study only included the active NR and NAD+ arms to further evaluate tolerability and comfort of the IV.
The purpose of this work is to establish and quantify the safety and efficacy of IV administration of ChromaDex's Niagen®, nicotinamide riboside chloride in comparison to currently available IV NAD+, a saline IV, and orally administered Niagen®
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
53
NAD+ enables cells to generate cellular energy from the food that one eats
NR is a unique member of the vitamin B3 family. Cells can use NR to create nicotinamide adenine dinucleotide (NAD+), which is an essential molecule found in every living cell. Patients in this arm received an IV administration.
NR is a unique member of the vitamin B3 family. Cells can use NR to create nicotinamide adenine dinucleotide (NAD+), which is an essential molecule found in every living cell. Patients in this arm received an oral administration.
Nutraceuticals Research Institute
Franklin, Tennessee, United States
Blood Pressure
blood pressure, systolic and diastolic, will be measured
Time frame: immediately before the intervention, immediately after the intervention, 3 and 6 hours post-intervention, and at the 24 hour visit.
Heart rate
heart rate will be measured
Time frame: immediately before the intervention, immediately after the intervention, 3 and 6 hours post-intervention, and at the 24 hour visit.
Total NAD measured through dried blood spot testing
NAD analysis will be developed from dried blood spots obtained by pricking a finger
Time frame: Blood spot data is collected at baseline, immediately after the intervention, 3 hours after the intervention, 6 hours after the intervention,on day 2, 7, and 14.
Glucose
Total glucose in blood via mg/dL
Time frame: baseline, at 3 hours, and 24 hours post administration of intervention
Insulin Levels
Total insulin in blood via mcU/mL
Time frame: baseline, at 3 hours, and 24 hours post administration of intervention
total NAD measured through blood and plasma
NAD analysis conducted on whole blood and plasma samples
Time frame: baseline, at 3 hours, and 24 hours post administration of intervention
Tolerable Infusion Rate
The total amount of time it takes patients to comfortably receive the IV
Time frame: through intervention completion, an average of 2 hours
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These individuals received a saline IV
Complete Blood Count
A complete blood count with differential will be evaluated through whole blood samples
Time frame: baseline, at 3 hours, and 24 hours post administration of intervention
Comprehensive Metabolic Panel
comprehensive metabolic panel will be evaluated through whole blood samples
Time frame: baseline, at 3 hours, and 24 hours post administration of intervention
Sleep Scale
This is a validated scale measuring 7 subdomains of sleep. It is measured on a likert scale. Scores on each subdomain can range from 5-42 with higher scores indicating greater quality of sleep
Time frame: Change from baseline at day 14
Energy Scale
This is a validated scale measuring 6 subdomains of energy. It is measured on a likert scale. Scores on each subdomain can range from 5 to 42, with higher scores indicating greater energy levels.
Time frame: Change from baseline at day 14