Selection Protocol for Liver Transplantation in Patients Aged Over 70 Years

Azienda Ospedaliera di Padova18 enrolled

Overview

Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates typically have an age-associated burden of comorbid conditions that can pose several clinical challenges during the selection/evaluation process for LT. Specific algorithms for elderly patient selection for LT are not well established; however, consensus agreement is that elderly LT candidates need a more rigorous selection process. This study proposes a "step by step" algorithm of selection for liver transplant candidates more than 70 years.

Study Type

OBSERVATIONAL

Enrollment

Conditions

End Stage Liver DIsease Liver Transplantation Old Age

Interventions

Liver transplantation

Eligibility

Sex: ALLMin age: 71 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>70 years and ≤ 75 years * Liver transplant from cadaveric donor * First liver transplant * End stage liver disease or liver tumor Exclusion Criteria: * Age ≤ 70 years * Living donor liver transplant * Previous liver transplant * Liver transplant for acute liver failure

Outcomes

Primary Outcomes

1 year patient survival

Overall patients survival at 12 months from liver transplantation

Time frame: 12 months

Secondary Outcomes

1 year graft survival

Overall graft survival at 12 months from liver transplantation

Time frame: 12 months

3 months mortality and morbidity

Mortality and morbidity rates at 3 months from liver transplantation

Time frame: 3 months

Central Contacts

Umberto Cillo, Prof

CONTACT

049.8212211-1897 cillo@unipd.it

Alessandro Vitale, Prof