The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are : 1. Does postoperative dexmedetomidine reduce the incidence of delirium after lung surgery? 2. Does postoperative dexmedetomidine introduce other medical problems? Researchers will compare dexmedetomidine and sufentanil to see if dexmedetomidine works to reduce delirium. Participants will undergo routine postoperative care: 1. Patient-controlled self anesthesia with sufentanil only or combination of sufentanil and dexmedetomidine 2. Postoperative visit twice a day for at least seven days
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
287
Combining with 3 μg.kg-1 sufentanil, 3 μg.kg-1 dexmedetomidine is injected through intravenous patient controlled anesthesia pump in a 2 ml bolus with 20 minutes lock-out, and a background infusion rate of 2 ml per hour.
3 μg.kg-1 sufentanil is injected through intravenous patient controlled anesthesia pump in a 2 ml bolus with 20 minutes lock-out, and a background infusion rate of 2 ml per hour.
Kunming Children's Hospital
Kunming, Yunnan, China
Incidence of postoperative delirium
Time frame: Delirium is assessed at 8 am and 8 pm for 3 days after surgery
Incidence of postoperative nausea and vomiting
Time frame: Assessed twice a day for 7days after surgery
incidence of postoperative complications
Other postoperative complications including including hypotension, hypertension, bradycardia, tachycardia, and hypoxemia
Time frame: Assessed daily for 3 days after surgery
Pain intensities
patient pain assessed using numeric rating scale, ranged from 0 to 11, higher score indicate higher pain intensity
Time frame: Assessed daily at 8 am for 3 days after surgery
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