The goal of this trial is to learn if the addition of oscillometry with reversibility testing increases diagnostic accuracy in adult asthma diagnosis, when added to current standard of care tests: spirometry with reversibility testing and Fractional Exhaled Nitric Oxide (FeNO). The main question it aims to answer is: \- Does oscillometry with reversibility testing increase diagnostic accuracy in detection of asthma in adults when added to spirometry with reversibility and FeNO? Researchers will evaluate the diagnostic accuracy of this approach with the reference standard, which is a clinically adjudicated diagnosis of asthma by two respiratory clinicians based on history and investigation results. Participants will * Undergo oscillometry testing alongside their routine asthma investigations within their scheduled clinic visit * Optionally participate in our sub-studies on new breath and nasal swab tests for asthma * Optionally participate in our qualitative substudy on patients views and attitudes to asthma testing and oscillometry
Study Type
OBSERVATIONAL
Enrollment
225
Oscillometry is a test that uses sound waves to measure the mechanical properties in the lungs during tidal breathing
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Imperial College Healthcare NHS Trust
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
To evaluate the diagnostic accuracy (sensitivity, specificity) of a combination of oscillometry ± reversibility, spirometry ± reversibility and FeNO
To evaluate the diagnostic accuracy (sensitivity, specificity) of a combination of oscillometry ± reversibility, spirometry ± reversibility and FeNO for adult asthma diagnosis compared to the diagnostic reference standard.
Time frame: 6 months
To conduct an analysis comparing the diagnostic accuracy of (i) oscillometry ± reversibility with spirometry ± reversibility, (ii) spirometry±reversibility with FeNO and (iii) oscillometry ±reversibility and FeNO
To compare the sensitivity and specificity of pairwise permutations of testing
Time frame: 6 months
To compare the concordance of positive and negative test results for (i) oscillometry±reversibility, (ii) spirometry ±reversibility and (iii) Fractional Exhaled Nitric Oxide (FeNO)
To assess the degree of agreement between each of the diagnostic tests
Time frame: 6 months
To collect data on (i) testing time, (ii) testing burden, (iii) general feasibility of implementation of the asthma diagnostic tests
We will collect data on feasibility on each of the diagnostics (spirometry, FeNO, oscillometry)
Time frame: 6 months
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