The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
90
10mL of 100mg/mL TXA will be administered into the surgical wound prior closure.
10mL of 100mg/mL normal saline will be administered into the surgical wound prior closure.
Toronto Western Hospital
Toronto, Ontario, Canada
RECRUITINGacute post-op pain
It will be assessed with VAS 0 to 10cm, with higher score indicating worse pain.
Time frame: 24 hours to 72 hours postoperatively
opioid use
Opioid use will be recorded on patients' medication diary
Time frame: 1, 2, and 6-week post-surgery
persistent pain
It will be assessed with VAS 0 to 10cm, with higher score indicating worse pain.
Time frame: 1, 2, and 6-week post-surgery
unscheduled hand-related procedures
clinic/emergency unit visits or any issue or events related to the condition that might lead participant to visit the emergency room, be seen by a doctor, or undergo any intervention more frequently than the usual visits
Time frame: 1, 2, and 6-week post-surgery
Patient reported function
will be assessed using the disabilities of the arm, shoulder and hand questionnaire (DASH) score 0 to 100, with higher score indicating more disability.
Time frame: 1, 2, and 6-week post-surgery
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