The goal of this clinical trial is to learn if vitamin C and N-acetylcysteine work to improve shoulder functional score after rotator cuff repair. It will also learn about the safety of vitamin C and N-acetylcysteine. The main questions it aims to answer are: Do vitamin C and N-acetylcysteine improve the shoulder functional score of participants? Do vitamin C and N-acetylcysteine improve healing of rotator tendon? Researchers will compare vitamin C and N-acetylcysteine to a placebo (a look-alike substance that contains no drug) to see if vitamin C and N-acetylcysteine works to improve shoulder functional score after rotator cuff repair. Participants will: Take vitamin C and N-acetylcysteine or a placebo every day for 45 days. Visit the OPD three times at 2 week, 6 month and 12 month after surgery for checkups and tests.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
110
Vitamin C (solution) 500 mg IV q4h for 4 doses PO d0 Vitamin C (tablet) 100mg 5 tab PO BID for 45 days
NAC (effervescent) 600mg 1 tab PO OD for 45 days
pharmacologically inactive substance
ASES score
American Shoulder and Elbow Surgeons (ASES) Shoulder Score
Time frame: 6 months after surgery
UCLA shoulder scale
The University of California-Los Angeles (UCLA) shoulder scale
Time frame: 6 months after surgery
WORC index
Western Ontario Rotator Cuff Index
Time frame: 6 months after surgery
Tendon healing at 6 months postoperatively
Sugaya ultrasound classification
Time frame: 6 months after surgery
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