The aim of the present study is to investigate the effects of different meal interventions on cognition (i.e., learning and decision making) and brain activity in healthy participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Participants receive a standardized meal with one type of macronutrient composition in one experimental session and the other type in a different experimental session a few days apart (within-subjects crossover design; i.e. order counterbalanced)
University of Vienna
Vienna, Austria
RECRUITINGChanges in cognition/behavior I
Changes in learning behavior assessed via computer-based learning task ("predictive inference task") which tracks choices and response times (allows for calculation of learning-related scores: change in prediction choice following feedback)
Time frame: 3-4.5 hours (post-meal)
Changes in cognition/behavior II
Changes in decision-making behavior assessed via computer-based decision task ("gamble task") which tracks choices (calculation of gamble acceptance frequencies) and response times.
Time frame: 3-4.5 hours (post-meal)
Changes in brain activity
Changes in brain activity measured via functional magnetic resonance imaging;
Time frame: 3-4.5 hours (post-meal)
Changes in metabolic parameters I
Changes in the concentrations of amino acids (assessed via blood samples and chemical analysis)
Time frame: from baseline (prior meal) to approx. 4.5 hours after meal at several time points
Changes in metabolic parameters II
Changes in the concentrations of glucose (assessed via blood samples and chemical analysis)
Time frame: from baseline (prior meal) to approx. 4.5 hours after meal at several time points
Changes in metabolic parameters III
Changes in the concentrations of insulin (assessed via blood samples and chemical analysis)
Time frame: from baseline (prior meal) to approx. 4.5 hours after meal at several time points
Changes in metabolic parameters IV
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Changes in the concentration of cortisol (assessed via saliva samples and chemical analysis)
Time frame: from baseline (prior meal) to approx. 4.5 hours after meal at several time points
Changes in subjective affective state
Changes in reported affect ("Multidimensionaler Befindlichkeitsfragebogen" - multidimensional mood scale; Steyer et al., 1997)
Time frame: from baseline (prior meal) to approx. 4.5 hours after meal at several time points
Changes in experienced hunger
Changes in subjective reported hunger (assessed via single-item Likert-Scale)
Time frame: rom baseline (prior meal) to approx. 4.5 hours after meal at several time points