Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran

Inclusion and exclusion criteria for healthy subjects were consistent with bioequivalence studies. Inclusion Criteria: 1. Age 18-89 years; 2. ECG meeting the diagnostic criteria for atrial fibrillation; 3. Provide at least one valid blood sample for SNP testing; 4. no contraindication to anticoagulation, blood counts and coagulation times within normal reference values, and negative urine and stool occult blood; 5. not have had any stroke in the 6 months prior to enrollment. Exclusion Criteria: 1. Cardiac ultrasound suggestive of moderate-to-severe mitral stenosis or after mechanical valve replacement; 2. severe hepatic injury or renal insufficiency (estimated glomerular filtration rate \[eGFR\] \<30 mL/(min\*1.73m2)) 3. History of stroke or peripheral arterial embolism during dosing; 4. patients at high risk of bleeding, such as history of bleeding, hematologic disorders, other disorders requiring anticoagulant therapy, peptic ulcer and other bleeding, and blood pressure \>180/110 mmHg; 5. Combination of other serious diseases, such as malignant tumors, severe hepatic and renal insufficiency; 6. history of allergy to dabigatran and warfarin.