This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.
Participants will engage in three distinct eating plans: a standard diet with usual carbohydrate and calorie levels, a low-carb diet with typical calories, and a low-carb diet with reduced calories. Each diet is followed for a single day, with subsequent monitoring to assess how the body processes food and manages hunger after a meal. The goal is to understand the potential metabolic benefits of reducing carbohydrate intake, either alone or in combination with calorie reduction. This research aims to identify simpler dietary strategies that could improve heart health and assist in weight management without the need for severe calorie restriction or fasting, offering valuable insights for enhancing health outcomes in overweight individuals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
12
nEB diet first, then LC25 and LCEB in random order with a 5 days washout between each diet
LC25 diet first, then nEB and LCEB in random order with a 5 days washout between each diet
LCEB diet first, then LC25 and nEB in random order with a 5 days washout between each diet
University of Surrey
Guildford, United Kingdom
Biomarkers in blood Measured
Measured with ELISA assay and clinical analyser (INDIKO)
Time frame: 8 hours (fasting and post-meal)
Resting metabolic rate
Measured with indirect calorimetry (GEM)
Time frame: 8 hours (fasting and post-meal)
Perceived Appetite Scores
Measured with a Visual Analog Scale
Time frame: 8 hours (fasting and post-meal)
Food intake
Measured using food diaries
Time frame: baseline and after each diet arm for 1 day
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