Idiopathic Generalized Epilepsy Syndromes

Shen Chun-Hong200 enrolled

Overview

The idiopathic generalized epilepsies (IGEs) have historically included the syndromes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCA). Recognition of the IGEs is important for clinical care, as it informs diagnosis, prevents unnecessary investigation, allows optimal selection of anti-seizure medications (ASMs), and provides prognostic guidance. According to the new ILAE definition in 2022, the study aims to describe the clinical features, electroencephalographic, imaging findings and long-term prognosis.

the Long-term prognosis include the rate of drug-resistent epilepsy, relapse after drug withdrawn, common comorbidities such as mood disorders, attention deficit hyperactivity disorder (ADHD) and learning disabilities.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Epilepsy Epilepsy, Idiopathic Generalized

Eligibility

Sex: ALLMin age: 4 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients are consecutively and prospectively enrolled from epilepsy center, with newly diagnosed epilepsy or established epilepsy. * Patients have a diagnosis of idiopathic generalized epilepsy (IGE), according to the 2022 diagnostic criteria. * Comprehensive clinical information is collected, and 24 hour video-electroencephalography is performed. * Sign the informed consent forms. Exclusion Criteria: * Other epilepsy syndromes are considered during follow-up, such as genetic generalized epilepsy. * Lost to follow-up

Outcomes

Primary Outcomes

The proportion of drug-resistent epilepsy

We defined drug-resistant cases as those patients who have failed two or more trials of broad-spectrum ASMs or those otherwise indicated in IGE syndromes